Spinach: Nutrients, What Research Shows and Safety
What spinach (Spinacia oleracea) offers, what research shows on heart health and eyes, and the safety facts on warfarin, oxalate stones, nitrate and food safety.
Content last updated . This page has not been medically reviewed.

Spinach (Spinacia oleracea L.) is a leafy vegetable in the amaranth family (Amaranthaceae). The leaves are eaten raw in salads or cooked, and people eat it for its vitamins, minerals and plant pigments. This page keeps the whole food apart from supplements, extracts and hype, and says plainly what research does and does not show.
Read this first
- Warfarin: spinach is very rich in vitamin K, which affects how this blood thinner works. The NHS says you do not need to avoid such foods, but should ask your warfarin clinic for advice. [3] MedlinePlus says sudden changes in vitamin K intake can change how the medicine works. [2] Keep to the clinic's advice and do not change a prescribed medicine on your own.
- Kidney stones: the US kidney institute (NIDDK) names spinach as a high-oxalate food to limit if you have had calcium oxalate stones. [4]
- Kidney disease and potassium: spinach has a lot of potassium (558 mg per 100 g). [1] People with kidney problems, and people taking ACE inhibitors, ARBs or potassium-sparing diuretics, should ask a clinician about potassium-rich foods. [8]
- Allergy: a food allergy is possible with any food. For trouble breathing or swelling of the face or throat, call 911.
- Evidence in one line: eating more green leafy vegetables is linked to lower heart disease in observational studies, but trials of greens have not shown clear effects on blood pressure or artery function. [11]
What is in it (USDA values)
Raw spinach, USDA FoodData Central item 168462 (SR Legacy). [1] USDA household portion: 1 cup of raw leaves = 30 g.
| Nutrient | Per 100 g | Per typical serving (1 cup raw, 30 g) | % Daily Value per serving |
|---|---|---|---|
| Energy | 23 kcal | 6.9 kcal | n/a |
| Fiber | 2.2 g | 0.66 g | 2% |
| Total sugars | 0.42 g | 0.13 g | n/a |
| Vitamin K | 482.9 µg | 144.9 µg | 121% |
| Vitamin A (RAE) | 469 µg | 140.7 µg | 16% |
| Folate (DFE) | 194 µg | 58.2 µg | 15% |
| Manganese | 0.9 mg | 0.27 mg | 12% |
| Vitamin C | 28.1 mg | 8.4 mg | 9% |
| Magnesium | 79 mg | 23.7 mg | 6% |
| Iron | 2.71 mg | 0.81 mg | 5% |
| Potassium | 558 mg | 167 mg | 4% |
| Calcium | 99 mg | 29.7 mg | 2% |
| Lutein + zeaxanthin | 12,198 µg | 3,659 µg | no Daily Value set |
% Daily Value uses the FDA 2016 Daily Values; values vary with variety, ripeness and storage. [1]
Plant compounds. USDA lists beta-carotene (5,626 µg per 100 g) and lutein plus zeaxanthin (12,198 µg per 100 g) in raw spinach. [1] These are yellow-orange plant pigments (carotenoids). Beta-carotene is turned into vitamin A in the body, which is why vitamin A is high in the table. Spinach also contains nitrate, a natural compound that is discussed below and on our nitrate page. The evidence we read for lutein and eye health is from people, and it is mixed (see the table).
What research says
| Health goal | What the sources found | Strength of evidence | What was studied |
|---|---|---|---|
| Normal blood clotting (vitamin K) | Vitamin K is needed for normal clotting; leafy greens such as spinach are major dietary sources. [2] | Established | Whole food provides the vitamin; essential nutrient role |
| Folate intake | Dark green leafy vegetables are a natural folate source; low folate can cause some forms of anemia. [9] | Established (as a source of the nutrient) | Whole food; nutrient role |
| Heart disease risk | A 2026 meta-analysis found higher green leafy vegetable intake linked to lower cardiovascular disease (RR 0.89) and CVD death (RR 0.79) in observational studies. [11] A 2017 meta-analysis reported inverse associations for green leafy vegetables, and for all fruit and vegetables together a risk ratio of 0.92 per 200 g a day. [12] | Promising but limited (observational; people who eat greens differ in other ways) | Cohort studies of green leafy vegetables in general, not spinach alone |
| Blood pressure and artery function | The same 2026 review pooled 7 randomized trials of leafy greens: no significant change in artery function or in systolic or diastolic blood pressure. [11] | Mixed (observational links, no clear trial effect) | Leafy greens in general; whole food and nitrate-rich foods |
| Eye health (age-related macular degeneration) | The AREDS2 trial (4,203 people) gave lutein 10 mg plus zeaxanthin 2 mg as a supplement for about 5 years; it did not significantly reduce progression to advanced disease compared with placebo. [14] | Insufficient evidence | Supplement capsules in people already at risk, not spinach |
| Iron and anemia | MedlinePlus says iron in plant foods such as spinach is harder for the body to absorb, and that vitamin C helps absorption. [10] | Limited as an iron source | Nutrient information, no trial of spinach for anemia read |
| Physical performance | A 2025 systematic review of 4 small trials (94 people) of spinach extract (1 to 2 g; three used red spinach) reported improved performance measures; the authors say more research is needed. [15] | Promising but limited | Extract, short trials |
Eaten as food vs taken as a supplement or extract
The heart-health findings above come from people eating greens as part of their diet and cannot show that spinach itself prevents disease. The only spinach-specific trials we read in detail used a concentrated extract, not the vegetable. [15] The lutein trial used a supplement, and it also found that the beta-carotene supplement group had more lung cancers (2.0% versus 0.9%), mostly in former smokers. [14] That finding is about beta-carotene supplements, not spinach, but it shows that a nutrient in food and the same nutrient in a pill are not the same thing. Powders, juices and extracts are different products and are not covered by food evidence.
How much is a normal serving
This is information, not a prescription. The WHO healthy diet fact sheet (January 2026) says at least 400 g of fruits and vegetables a day for people older than 10. [17] The NHS counts 80 g of fresh, canned or frozen vegetables as one portion (last reviewed 9 June 2026). [16] The USDA household portion for raw spinach is 1 cup, or 30 g. [1] Cooked spinach shrinks a lot, so the same weight holds many more leaves. For cooking, freezing and canning effects, proper evidence not found in the sources we read; see fresh, frozen and canned produce.
Safety, allergy and medicines
- Warfarin and vitamin K. Vitamin K helps blood clot, and spinach is a major source. [2] The NHS says foods high in vitamin K such as spinach and other leafy greens can affect how warfarin works; you do not need to avoid them, but should ask your warfarin clinic for advice and speak to a doctor before big diet changes. The NHS also says not to take vitamin K supplements while on warfarin. [3] MedlinePlus adds that steady intake from day to day matters, because sudden changes can change the effect. [2] See foods and medicine interactions.
- Oxalate and kidney stones. NIDDK lists spinach among high-oxalate foods for people who have had calcium oxalate stones, and says drinking enough liquid, mainly water, is the most important step for stone prevention. [4] In a small 2025 study of 21 healthy adults eating 10 oz of spinach, urinary oxalate rose in most people (about 2% to 12% of the oxalate was absorbed), and drinking extra water lowered the spikes in oxalate concentration. [5] Healthy non-stone-formers were studied; the result does not tell a person with stones what to do. Ask a clinician which stone type you have. See foods, kidney disease, potassium and oxalates.
- Potassium, kidney disease and medicines. MedlinePlus says people with kidney problems, particularly on dialysis, should not eat too many potassium-rich foods, and that ACE inhibitors, ARBs and potassium-sparing diuretics (spironolactone, triamterene, amiloride) are common causes of high blood potassium. [8] MedlinePlus does not name spinach on that page, but USDA lists 558 mg of potassium per 100 g. [1, 8]
- Nitrate. Spinach contains natural nitrate. Our nitrate page found mixed blood pressure results for nitrate supplements and beet juice, and a meta-analysis of 16 small trials reported a lower systolic pressure with inorganic nitrate or beetroot juice (-4.4 mm Hg), not spinach. [13] The leafy-greens trials pooled in 2026 showed no significant blood pressure change. [11] Whether nitrate in spinach is a risk for young infants: proper evidence not found in the official sources we could read; we make no claim. A parent worried about homemade baby food can ask a pediatrician.
- Food poisoning from leafy greens. The FDA lists a closed 2024 E. coli O157:H7 outbreak linked to spinach (28 cases) and others linked to romaine lettuce. [7] See the food-safety section below.
- Allergy. The sources we read did not describe spinach allergy specifically, so we give no figures. For trouble breathing or swelling of the face or throat, call 911. See food allergy basics and emergency signs.
- Pregnancy. Folate is found in leafy greens, but MedlinePlus says people thinking about pregnancy should take a folic acid supplement because food alone can be hard. [9] Pregnant people should follow official food-safety advice; see foods in pregnancy.
- Pesticide residues, goitrogens, histamine, FODMAPs: proper evidence not found in the sources we read for spinach, so no claim is made.
Choosing, storing and food safety
- Wash fresh produce under running water, then dry it with a clean towel. Washing reduces bacteria but does not remove all of them. Do not wash with soap, detergent or commercial produce wash. [6]
- Packages labeled "pre-washed" or "ready-to-eat" can be used without more washing. If you rewash them, keep them away from unclean surfaces and utensils. [6]
- Keep leafy greens and all pre-cut or packaged produce in a refrigerator at 40°F (4°C) or below. When buying bagged greens, choose ones kept cold. [6]
- Check the FDA outbreak list if you hear of a recall of bagged greens. [7] Raw sprouts are a separate risk; see raw sprouts, raw milk and undercooked foods.
Related pages
Health connections for Spinach
What research links to eating or drinking this food, and how strong the evidence is. Many studies are observational or use juice, powder, oil or extracts rather than the food as eaten; each card says which.
Vitamin K intake and normal blood clotting
Established roleSpinach is a major food source of vitamin K, which the body needs for normal blood clotting. One USDA cup (30 g) of raw leaves gives about 145 micrograms, over 100% of the FDA Daily Value.
Supplements: A varied diet normally supplies it; this page does not show that extra vitamin K from any source adds benefit.
Folate from leafy greens
Deficiency linkDark green leafy vegetables are a natural folate source, and low folate can cause some forms of anemia. One cup of raw spinach gives about 15% of the Daily Value for folate.
Supplements: Food helps meet needs; MedlinePlus says people planning pregnancy should take folic acid supplements because food alone can be hard.
Green leafy vegetables and heart disease risk
Preliminary or mixedObservational studies link more green leafy vegetables to lower cardiovascular disease (RR 0.89) and CVD death (RR 0.79). These studies cannot prove the greens are the cause.
Supplements: Findings are from eating vegetables as food; no supplement evidence is claimed.
Leafy greens, nitrate and blood pressure
Preliminary or mixedSpinach contains natural nitrate. Pooled randomized trials of leafy greens found no significant change in blood pressure or artery function, while beetroot juice and nitrate salts lowered systolic pressure by about 4 mm Hg in small trials.
Supplements: Mixed; results for beetroot juice or nitrate salts do not transfer to spinach.
Lutein, zeaxanthin and eye health
Not enough evidenceSpinach is rich in lutein and zeaxanthin (12,198 micrograms per 100 g, USDA). In the AREDS2 trial, a lutein and zeaxanthin supplement did not significantly slow progression to advanced macular degeneration compared with placebo.
Supplements: No good evidence of added benefit from the supplement in that trial; spinach itself was not tested.
Iron from spinach
Not enough evidenceSpinach contains iron (2.71 mg per 100 g), but MedlinePlus says iron in plant foods such as spinach is harder for the body to absorb, and that vitamin C helps absorption.
Supplements: No trial of spinach for iron deficiency was read; a food rich in a nutrient is not proof it treats anemia.
Spinach extract and physical performance
Preliminary or mixedA 2025 systematic review of four small randomized trials (94 people) of spinach extract (1 to 2 g, short follow-up) reported improved performance measures; the authors say more research is needed.
Supplements: Small, short trials of an extract; not evidence for eating spinach.
Connected topics
Open a group to see how each topic connects and how strong the evidence is.
Health goals (1)
- Heart HealthPreliminary or mixed
Eating more green leafy vegetables is linked to lower heart disease in observational studies, but trials of greens showed no clear blood pressure or artery effect, and the studies cannot prove cause.
Body systems (4)
- Cardiovascular SystemPreliminary or mixed
Eating more green leafy vegetables is linked to lower heart disease in observational studies, but trials of greens showed no clear blood pressure or artery effect, and the studies cannot prove cause.
- Heart & CirculationPreliminary or mixed
Eating more green leafy vegetables is linked to lower heart disease in observational studies, but trials of greens showed no clear blood pressure or artery effect, and the studies cannot prove cause.
- Kidney & UrinaryDocumented risk
Spinach is high in oxalate, which matters for people who form calcium oxalate stones, and rich in potassium, which matters in kidney disease.
- Urinary SystemDocumented risk
NIDDK names spinach among high-oxalate foods to limit after calcium oxalate stones.
Body parts (2)
- HeartPreliminary or mixed
Eating more green leafy vegetables is linked to lower heart disease in observational studies, but trials of greens showed no clear blood pressure or artery effect, and the studies cannot prove cause.
- KidneysDocumented risk
High oxalate and potassium content matter for people with stones or kidney disease; ask a clinician.
Root causes (2)
- Medication Side EffectsDocumented risk
Vitamin K in spinach can change how warfarin works; keep intake steady and ask the warfarin clinic. High potassium matters with ACE inhibitors, ARBs and potassium-sparing diuretics.
- Nutrient DeficiencyDeficiency link
Leafy greens such as spinach are a dietary source of folate and vitamin K, nutrients whose deficiency has known effects; food does not treat a diagnosed deficiency by itself.
Habits (1)
- Balanced NutritionPreliminary or mixed
WHO advises at least 400 g of fruits and vegetables a day for people over 10; spinach can be one of them. This is general advice, not specific to spinach.
Conditions & symptoms (4)
- NephrolithiasisDocumented risk
NIDDK lists spinach among high-oxalate foods to limit for people who have had calcium oxalate stones; drinking enough liquid is the main prevention step.
- Escherichia Coli InfectionsDocumented risk
The FDA lists a closed 2024 E. coli O157:H7 outbreak linked to spinach; wash produce under running water, keep it refrigerated and follow recall notices.
- HyperkalemiaDocumented risk
Spinach is potassium-rich; people with kidney disease or on ACE inhibitors, ARBs or potassium-sparing diuretics should ask a clinician about potassium-rich foods.
- Megaloblastic Anemia Due To Folate DeficiencyDeficiency link
Dark green leafy vegetables are a natural folate source and low folate can cause some anemias; spinach does not treat a diagnosed deficiency by itself.
Documented risks and interactions (4)
- Vitamin K foods and warfarin. Spinach can change how the blood thinner warfarin works. The NHS says you do not need to avoid such foods but should ask your warfarin clinic; MedlinePlus says sudden changes in intake can change the medicine's effect.
- Oxalate and kidney stones. Spinach is high in oxalate. NIDDK says to limit it if you have had calcium oxalate stones. A small study in healthy adults found urine oxalate rose after a large spinach meal and that extra water lowered the spikes.
- Potassium, kidney disease and medicines. Spinach is rich in potassium (558 mg per 100 g). MedlinePlus says people with kidney problems should not eat too many potassium-rich foods, and that ACE inhibitors, ARBs and potassium-sparing diuretics can raise blood potassium.
- Food safety of leafy greens. The FDA lists a closed 2024 E. coli O157:H7 outbreak linked to spinach (28 cases) and others linked to romaine. Washing under running water reduces but does not remove bacteria; do not use soap; keep greens refrigerated.
Frequently asked questions
Can I eat spinach if I take warfarin?
Usually yes, but talk to your warfarin clinic. The NHS says you do not need to avoid vitamin K-rich foods such as spinach, but you should ask the clinic for advice. [3] MedlinePlus says sudden changes in how much you eat can change the effect of the medicine. [2]
Is spinach bad for kidney stones?
Spinach is high in oxalate, and NIDDK lists it among foods to limit if you have had calcium oxalate stones. [4] NIDDK also calls drinking enough liquid, mainly water, the most important prevention step. [4] Ask a clinician about your stone type.
Does spinach lower blood pressure?
Not clearly. A 2026 meta-analysis of 7 randomized trials of leafy greens found no significant change in blood pressure or artery function, although observational studies link greens to lower heart disease. [11]
Is spinach a good source of iron?
It contains iron (2.71 mg per 100 g), but MedlinePlus says iron in plant foods like spinach is harder to absorb, and that vitamin C helps. [1, 10]
Do I need to wash bagged spinach?
Packages labeled pre-washed or ready-to-eat can be used without more washing, the FDA says. Keep them refrigerated, and do not use soap or produce wash. [6]
References
- U.S. Department of Agriculture. FoodData Central: Spinach, raw (FDC ID 168462, SR Legacy). SR Legacy, April 2018 release. Read 2026-10-23.
- MedlinePlus (U.S. National Library of Medicine). Vitamin K. Review date 21 January 2025. Read 2026-10-23.
- NHS (UK). Warfarin: medicine used to prevent and treat blood clots. Last reviewed 24 February 2026. Read 2026-10-23.
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Eating, Diet, & Nutrition for Kidney Stones. Read 2026-10-23.
- Lemack B et al. Spot Urine Oxalate Testing in a Controlled Trial of Forced Hydration and Spinach Consumption. Urology 2025. PMID 40744229. Abstract read 2026-10-23.
- U.S. Food and Drug Administration. Selecting and Serving Produce Safely. Read 2026-10-23.
- U.S. Food and Drug Administration. Investigations of Foodborne Illness Outbreaks. Read 2026-10-23.
- MedlinePlus (U.S. National Library of Medicine). Potassium in diet. Review date 30 April 2026. Read 2026-10-23.
- MedlinePlus (U.S. National Library of Medicine). Folic acid in the diet. Review date 3 February 2025. Read 2026-10-23.
- MedlinePlus (U.S. National Library of Medicine). Iron in diet. Review date 21 January 2025. Read 2026-10-23.
- Kaewpradup T et al. Dietary Green Leafy Vegetables and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Foods 2026. PMID 42587937. Abstract read 2026-10-23.
- Aune D et al. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies. Int J Epidemiol 2017. PMID 28338764. Abstract read 2026-10-23.
- Siervo M et al. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013. PMID 23596162. Abstract read 2026-10-23.
- Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the AREDS2 randomized clinical trial. JAMA 2013. PMID 23644932. Abstract read 2026-10-23.
- Wen J et al. Improved Effect of Spinach Extract on Physical Performance: A Systematic Review of Randomized Controlled Trials. Cureus 2025. PMID 39991395. Abstract read 2026-10-23.
- NHS (UK). 5 A DAY: what counts. Last reviewed 9 June 2026. Read 2026-10-23.
- World Health Organization. Healthy diet fact sheet. Date shown 26 January 2026. Read 2026-10-23.