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Common TCM Patterns Explained: Qi Deficiency, Yin Deficiency, Liver Qi Stagnation and More

What practitioners mean by qi deficiency, yin deficiency, liver qi stagnation, spleen qi deficiency and blood deficiency, and what studies say about agreement and biology.

Content last updated . This page has not been medically reviewed.

Patterns are not diagnoses

In Chinese medicine, a pattern (zheng, often translated "syndrome") is a highly generalized overall judgment drawn from a person's symptoms. [1] It is a traditional framework. It is not a disease and it is not a lab result. The same medical condition can be given different patterns in different people, and the pattern is then used to guide a practitioner's choices (see pattern differentiation).

ICD-11 has an optional traditional medicine chapter so these patterns can be recorded and counted. [2] WHO says the chapter neither judges nor endorses their scientific validity. [2] This page describes the patterns in the way research papers describe them. It does not match any herb or treatment to a pattern.

Common patterns and what research says

PatternHow studies describe itWhat was foundEvidence label
Qi deficiencyQi is described as the body's vital energy that keeps blood moving, warms the body and fights disease. [3] One team screened for exhaustion, a weak voice and lack of strength to move. [3]In 198 cancer patients in Taiwan, everyone with cancer-related fatigue was labeled qi-deficient, and so were 39.9% of those without fatigue. [3] The authors noted there was no existing diagnostic tool and wrote their own three-question screen. [3]Insufficient evidence
Spleen qi deficiencyDescribed as a basic TCM pattern, linked in papers to digestive diseases and whole-body complaints such as chronic fatigue. [4]Three practitioners agreed very well on this pattern in 45 adults, the only one of the Zang-Fu patterns that did. [5] Its biological basis "has not been clearly elucidated," its authors say. [4] A Korean-medicine version was linked to lower resting metabolic rate in 954 people. [6]Mixed
Yin deficiency (including kidney and liver-kidney yin deficiency)In one cirrhosis study: blurred vision, tinnitus, dry eyes, bitter taste and dry mouth, poor libido, soreness of the waist and knees. [7]In a double-blind trial in 50 patients with "kidney-yin deficiency," a classic formula did not beat placebo as a group (see below). [8]Insufficient evidence
Yang deficiencyAversion to cold; often grouped with the "cold" pattern. [9]In 283 adults, yang deficiency went with lower energy metabolism in white blood cells. [9] Proper evidence not found for a clear standalone description beyond cold intolerance.Preclinical
Liver qi stagnation (studied here as the related "liver qi invading the stomach")In functional dyspepsia, the features listed for this pattern included depressed mood and oppression in the chest. [10]Severe anxiety was associated with it (odds ratio 1.20). [10]Association only
Blood deficiency (as qi-blood deficiency)Fatigue, shortness of breath and reluctance to speak are listed as core features. [11]A study of 10 people with chronic fatigue syndrome and this pattern, 10 with another pattern and 10 controls found different patterns of phosphorylated serum proteins. [11]Preclinical

Blood deficiency is not the same as anemia. Anemia is found with a blood test that counts red blood cells. [12] Its symptoms, such as tiredness, shortness of breath and noticeable heartbeats, overlap with the fatigue described above. [12] If you are tired, ask your doctor about testing instead of assuming the pattern.

Do practitioners agree?

Agreement depends on the step.
  • In 40 people with knee osteoarthritis, two experienced practitioners examined each person separately. Agreement was relatively good for questions and for listening/smelling, but generally low for visual inspection and touch. [13]
  • Three practitioners examining 45 adults with mild high cholesterol had reasonably good agreement on the Eight Guiding Principles, but at the organ-pattern level it was very good for one pattern only (spleen qi deficiency). [5]
  • Gastroenterologists trained in Western medicine and TCM practitioners agreed on the syndrome type in 86.3% of 160 people with functional dyspepsia, when going by the main symptoms. [14]
  • Researchers state that without standard rules, agreement among practitioners is unsatisfactory. [15] Criteria for prediabetes patterns were found not clearly defined or standardized, leading to poor repeatability. [16] Between 52.7% and 59.6% of functional dyspepsia patients were given two or more patterns, and the commonest patterns differed between Hong Kong and Hunan. [10]

Label: mixed. Agreement can be reasonable in some conditions, but it is not guaranteed.

Do patterns have a measurable biology?

Several small studies searched blood, urine or gene activity for markers of a pattern. One cirrhosis study noted that no biological evidence yet supported pattern differentiation before reporting differences in urine metabolites between two patterns. [7] The chronic fatigue study above included only 10 people per group. [11] I found no independent replication in the sources read. Label: preclinical. See Traditional Frameworks vs Biomedical Explanations.

Does matching treatment to a pattern help?

The one direct test I found was an n-of-1 trial service in China: 50 patients with "kidney-yin deficiency" tried Liuwei Dihuang decoction and placebo in blinded crossover periods. [8] Of 47 who completed, 3 were responders and 28 non-responders; as a group there was no difference from placebo. [8] This does not prove the formula never helps, and it is a single small study (see Liu Wei Di Huang Wan). Label: insufficient evidence. For the larger picture see Does TCM Work?.

Frequently asked questions

Is qi deficiency a medical condition?

No. It is a traditional pattern. In one study the label overlapped with fatigue but also applied to many people without fatigue. [3] Persistent tiredness deserves a doctor's check. [17]

Is blood deficiency the same as anemia?

No. Anemia is identified by a blood test. [12] Blood deficiency is a traditional pattern described by symptoms like fatigue and shortness of breath. [11]

Can I work out my own pattern?

Not reliably. Even experienced practitioners agree more on some steps than others, and standard rules are lacking. [13][15] See why online TCM quizzes are unreliable.

Is liver qi stagnation a liver disease?

No. It is a traditional pattern, and in the digestive study its listed features included depressed mood and oppression in the chest, and it was linked to anxiety. [10] See Zang-Fu organ systems for how "liver" is used.

Does my pattern decide which herbs I am given?

In traditional practice, yes, in principle. But in the one blinded test I found, a formula for a named pattern did not beat placebo as a group. [8] Ask any practitioner what evidence supports a plan, and tell your doctor.

More details: evidence, limits and cautions

The details behind this page: cautions, limits of the evidence and where sources disagree. Open any note to read it.

Safety and when to get care
Tiredness lasting weeks needs a medical check, and the NHS advises not to self-diagnose. [17] A pattern name is not a mental health diagnosis either. If you feel unsafe or in crisis in the United States, call or text 988. Never stop prescribed medicines because of a pattern. Do not buy herbs by pattern name; read Chinese herbal product quality and interactions.
References
  1. Wang W, et al. Multi-omics driven paradigm for construction of TCM Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example. Chin Med. 2025 (full text via PubMed Central PMC11890557). Read 2026-10-22.
  2. World Health Organization. ICD-11 frequently asked questions: Traditional medicine. Read 2026-10-22.
  3. Hsu CH, et al. The relationship between qi deficiency, cancer-related fatigue and quality of life in cancer patients. J Tradit Complement Med. 2012 (full text via PubMed Central PMC3942915). Read 2026-10-22.
  4. Wang X, et al. Network pharmacology to uncover the biological basis of spleen qi deficiency syndrome and herbal treatment. Oxid Med Cell Longev. 2020. Read 2026-10-22.
  5. O'Brien KA, et al. An investigation into the reliability of Chinese medicine diagnosis according to Eight Guiding Principles and Zang-Fu Theory in Australians with hypercholesterolemia. J Altern Complement Med. 2009. Read 2026-10-22.
  6. Mun S, et al. Cold and spleen-qi deficiency patterns in Korean medicine are associated with low resting metabolic rate. Evid Based Complement Alternat Med. 2017. Read 2026-10-22.
  7. Wang X, et al. Urinary metabolite profiling offers potential for differentiation of liver-kidney yin deficiency and dampness-heat internal smoldering syndromes in posthepatitis B cirrhosis patients. Evid Based Complement Alternat Med. 2015 (full text via PubMed Central PMC4312628). Read 2026-10-22.
  8. Yuhong H, et al. An n-of-1 trial service in clinical practice: testing the effectiveness of Liuwei Dihuang decoction for kidney-Yin deficiency syndrome. Evid Based Complement Alternat Med. 2013. Read 2026-10-22.
  9. Ma G, et al. Association of traditional Chinese medicine body constitution and cold syndrome with leukocyte mitochondrial functions: an observational study. Medicine (Baltimore). 2023 (full text via PubMed Central PMC9902006). Read 2026-10-22.
  10. Ho L, et al. Quantification of prevalence, clinical characteristics, co-existence, and geographic variations of traditional Chinese medicine diagnostic patterns via latent tree analysis-based differentiation rules among functional dyspepsia patients. Chin Med. 2022 (full text via PubMed Central PMC9425972). Read 2026-10-22.
  11. Zhang J, et al. Phosphoproteomic analysis reveals differential associations between liver-spleen disharmony and qi-blood deficiency syndromes in chronic fatigue syndrome. J Transl Med. 2026 (full text via PubMed Central PMC13173925). Read 2026-10-22.
  12. National Health Service (England). Iron deficiency anaemia. Read 2026-10-22.
  13. Hua B, et al. Reliability of Chinese medicine diagnostic variables in the examination of patients with osteoarthritis of the knee. J Altern Complement Med. 2012. Read 2026-10-22.
  14. Song J, et al. Agreement of gastroenterologists in traditional Chinese medical differential diagnosis of functional dyspepsia compared with traditional Chinese medical practitioners. J Dig Dis. 2020. Read 2026-10-22.
  15. Ho L, et al. Latent tree analysis for the identification and differentiation of evidence-based Traditional Chinese Medicine diagnostic patterns: a primer for clinicians. Phytomedicine. 2022. Read 2026-10-22.
  16. Lan Q, et al. Analysis of traditional Chinese medicine syndrome elements and clinical symptoms in prediabetes: a systematic review. Medicine (Baltimore). 2024 (full text via PubMed Central PMC11224823). Read 2026-10-22.
  17. National Health Service (England). Tiredness and fatigue. Read 2026-10-22.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.