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Ingredient
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Gene Target
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Disease
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Trans-caffeic acid
4
Clinical Trials
3
Meta-Analyses
5
PubMed References
Top Conditions Studied with Trans-caffeic acid
📋 Sample Trials
NCT02556814
Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
Completed · Phase 4
NCT04648917
GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)
Unknown · Phase 3
NCT02351622
Caffeic Acid Tablets as a Second-line Therapy for ITP
Completed · Phase 3
📊 Sample Meta-Analyses
CRD42021215920
Caffeic acid and its derivatives potential therapeutics effects on different melanoma cell lines: a project to a sistematic review
CRD42023408316
Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a systematic review and meta-analysis
The main ingredient of caffeic acid tablet is caffeic acid, also known as "3, 4-
CRD42023408324
Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia: a systematic review and meta-analysis
Thrombocytopenias
📚 Sample References
PMID 33432954
Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models
Food Funct · 2021
PMID 33562019
Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib
Int J Mol Sci · 2021
PMID 33567596
Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
Nutrients · 2021
⚗️ All Ingredient data fields for Trans-caffeic acid
⚗️ Identity
Name
Trans-caffeic acid
Aliases / Synonyms
caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 501-16-6; 3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; (E)-3-(3,4-dihydroxyphenyl)acrylic acid
🧪 Chemistry
Molecular Weight
180.1590
LogP
1.1956
Drug-likeness
0.472
H-Bond Acceptors
3
H-Bond Donors
3
Rotatable Bonds
2
🔬 Structures
Canonical SMILES
C1=CC(=C(C=C1C=CC(=O)O)O)O
Isomeric SMILES
C1=CC(=C(C=C1/C=C/C(=O)O)O)O
InChIKey
QAIPRVGONGVQAS-DUXPYHPUSA-N
InChI
InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+
🔗 External References
🔍 Raw view — every non-empty column on this row (29 fields)
name
Trans-caffeic acid
common names
caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 501-16-6; 3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; (E)-3-(3,4-dihydroxyphenyl)acrylic acid
herb ingredient id
HBIN046726
canonical smiles
C1=CC(=C(C=C1C=CC(=O)O)O)O
isomeric smiles
C1=CC(=C(C=C1/C=C/C(=O)O)O)O
inchi
InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+
inchikey
QAIPRVGONGVQAS-DUXPYHPUSA-N
mol wt
180.1590
num h acceptors
3
num h donors
3
mol logp
1.1956
num rotatable bonds
2
drug likeness
0.472
tcmid ingredient id
33971; 34443; 32303
pubchem cid
689043
npass id
NPC294902
hit id
C1203
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