Holistic Remedies · Ingredient
Rutaecarpine
Formula: C18H13N3O · MW: 287.3219999999999 · Drug-likeness: 0.54
⚗️ Identity
Name
Rutaecarpine
Aliases / Synonyms
84-26-4; Rutecarpine; Rutacarpine; Rutaecarpin; Rhetine; 8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one; MFCD00210551; Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-; 8XZV289PRY
🧪 Chemistry
Molecular Weight
287.3220
LogP
3.1009
Drug-likeness
0.54
Oral Bioavailability
40.3000
H-Bond Acceptors
3
H-Bond Donors
1
🔗 External References
0
Clinical Trials
0
Meta-Analyses
11
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31874248
Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis
Free Radic Biol Med · 2020
PMID 33324227
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis
Front Pharmacol · 2020
PMID 33435214
Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes
Antioxidants (Basel) · 2021
PMID 33939251
Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia
J Cell Mol Med · 2021
PMID 34661951
Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-κB signaling pathways via calcitonin gene-related peptide
Phytother Res · 2021
PMID 34681769
Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism
Int J Mol Sci · 2021