Holistic Remedies · Ingredient
Morphine
Formula: C17H19NO3 · MW: 285.343 · Drug-likeness: 0.703
⚗️ Identity
Name
Morphine
Aliases / Synonyms
Morphia; Morphium; Morphin; Morphinum; (-)-Morphine; Morphina; Ospalivina; Duromorph; 57-27-2
🧪 Chemistry
Molecular Weight
285.3430
LogP
1.1981
Drug-likeness
0.703
Oral Bioavailability
24.6940
H-Bond Acceptors
4
H-Bond Donors
2
🔗 External References
278
Clinical Trials
46
Meta-Analyses
23
PubMed References
Top Conditions Studied with Morphine
📋 Sample Trials
NCT00921102
Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Section
Completed · Phase 4 · Cesarean Section|Anesthesia,Spinal|Posto
NCT00004390
Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia
Completed · Phase 3 · Pain|Herpes Zoster
NCT00004696
Study of Morphine in Postoperative Infants to Allow Normal Ventilation
Completed · Infant, Newborn, Diseases|Pain
NCT00125684
Bioavailability and Effectiveness of Transdermally Administered Morphine
Completed · Phase 1 · Cancer|Pain
NCT00142519
Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-operative Pain
Completed · Phase 2 · Pain
NCT00195910
Safety and Efficacy Study of Hydromorphone and Morphine
Completed · Phase 2 · Pain
📊 Sample Meta-Analyses
CRD42015018975
Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain [Cochrane Protocol]
The Cochrane Pain, Palliative and Supportive Care Group
CRD42015024937
Topical morphine versus local anaesthetic for the management of oral mucositis among patients with head and neck cancer undergoing treatment: a systematic review
Head and neck cancers include cancers of the mouth, tongue, salivary glands and
CRD42015026190
Morphine for neuropathic pain in adults [Cochrane Protocol]
The Cochrane Pain, Palliative and Supportive Care Group
CRD42016044075
Effectiveness and safety of fentanyl and morphine added to intrathecal bupivacaine for caesarean section
Patients coming for caesarean section generally undergo a spinal anesthetic rath
CRD42017060656
The efficacy and safety of morphine for analgesia in patients with presumed ischaemic acute cardiac chest pain: a systematic review and meta-analysis
Acute coronary syndrome is a leading cause of premature death. The term encompas
CRD42017074922
Neuraxial morphine and diamorphine after cesarean delivery: a systematic review of opioid induced respiratory depression
Respiratory depression.
📚 Sample References
PMID 31413370
Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward
Mol Psychiatry · 2021
PMID 31626971
Morphine decreases the function of primary human natural killer cells by both TLR4 and opioid receptor signaling
Brain Behav Immun · 2020
PMID 31751616
Epigenetic upregulation of hippocampal CXCL12 contributes to context spatial memory-associated morphine conditioning
Brain Behav Immun · 2020
PMID 31989355
Pellino1 Contributes to Morphine Tolerance by Microglia Activation via MAPK Signaling in the Spinal Cord of Mice
Cell Mol Neurobiol · 2020
PMID 32187535
Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway
Cell Rep · 2020
PMID 32524520
Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus
Mol Neurobiol · 2020
🏥 Linked Health Topics 12 · matched via study conditions
Abdominal Pain
phenotype
Appendicitis
syndrome
Renal Cell Carcinoma
disease
Delirium
disease
Hallux Valgus
disease
Low Back Pain
phenotype
Neonatal Abstinence Syndrome
syndrome
Otitis Media
syndrome
Pain
phenotype
Pain, Postoperative
phenotype
Postoperative Complications
group
Prostatic Neoplasms
group